职    称

教授

出生年月

1987.10

是否天中医博导

是

学    位

博士

联系电话

E-mail

suncp146@163.com

所在单位

大连医科大学

简  介

(限800字以内)

孙成鹏，男，博士，教授。基于多组学靶点识别技术，围绕中药药效物质和作用靶标，开展中药化学生物学研究，以第一作者或通讯作者在PNAS、ACS Cent. Sci.、Acta Pharm. Sin. B、Int. J. Biol. Sci.、J. Med. Chem.、Chinese Chem. Lett.等期刊发表SCI科研论文70篇，其中4篇IF>10，17篇IF>7，43篇IF>5。主持国家自然科学基金2项，省市课题3项，授权发明专利9项，参编教材3部。入选中华中医药学会青年人才托举工程，获辽宁省科技进步二等奖和大连市科技之星称号。担任世界中医药联合会-中药化学专业委员会理事、中国仪器仪表学会药物质量分析与过程控制分会理事和大连市药学会天然药物专业委员会委员；担任Front. Chem.客座编辑；担任Anal. Chim Acta、Bioorg. Chem.、Front. Pharmacol.、Phytochemistry、J. Agric. Food Chem.等期刊特约审稿人；担任Acta Materia Medica和沈阳药科大学学报青年编委。

代表性论文：

1. Macrophage inactivation by small molecule wedelolactone via targeting sEH for the treatment of LPS-induced acute lung injury. ACS Cent. Sci., 2023, 9, 440-456. (通讯作者，IF=18.728)

2. Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. PNAS, 2022, 119, 9, e2118818119. (第一作者，IF= 12.779)

3. Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury. Int. J. Biol. Sci., 2023, 19, 294-310. (通讯作者，IF=10.750)

4. Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma. Acta Pharm. Sin. B, 2018, 8, 242-251. (第一作者，IF=14.903)

5. Octacyclic and decacyclic ent-abietane dimers with cytotoxic activity from Euphorbia fischeriana steud. Chinese Chem. Lett., 2022, 33, 4261-4263. (通讯作者，IF= 8.455)

6. Discovery of soluble epoxide hydrolase inhibitors from chemical synthesis and natural products. J. Med. Chem. 2021, 64, 184-215. (第一作者，IF=8.039)

7. Alismanin A, a triterpenoid with a C34 skeleton from Alisma orientale as a natural agonist of human pregnane X receptor. Org. Lett., 2017, 19, 5645-5648. (通讯作者，IF= 6.492)

8. Investigation of the inhibitory effect of protostanes on human carboxylesterase 2 and their interaction: Inhibition kinetics and molecular stimulations. Int. J. Biol. Macromol., 2021, 167, 1262–1272. (通讯作者，IF= 8.025)

9. Natural soluble epoxide hydrolase inhibitors from Alisma orientale and their potential mechanism with soluble epoxide hydrolase. Int. J. Biol. Macromol., 2021, 183, 811-817. (通讯作者，IF= 8.025)

10. Natural soluble epoxide hydrolase inhibitors from Inula helenium and their interactions with soluble epoxide hydrolase. Int. J. Biol. Macromol., 2020, 158, 1362-1368. (通讯作者，IF= 8.025)