天津中医药大学中药学院研究员，中国药理学会心血管药理专业委员会委员，热心肠研究院智库专家，《中国消费者报》学术顾问，Molecular Medicine Reports等4家国际期刊编委，同时担任50余种SCI期刊的资深审稿人，先后主持国家自然科学基金、中国医学科学院青年医学人才项目等课题5项。迄今发表科研论文100篇，其中SCI论文73篇，总影响因子339。联合中国医学科学院药物研究所、药用植物研究所、中国科学院微生物所、高能物理研究所、国家纳米科学中心、浙江省农业科学院、北京市科学技术研究院、北京中医药大学等10家科研单位，以及肿瘤医院、北医三院、东直门医院、西苑中医院等多家三甲医院的13个专家组，共同组建了“中医药—肠道微生态联合研究团队”，旨在利用精准肠道微生态技术深入探究和挖掘具有提高免疫、抗肿瘤、抗代谢病和改善情绪的新型中药分子和益生菌，从分子、细胞、动物和人体临床等多个层面开展研究，开发新型药物，同时从肠道微生态的角度探究和揭示中医药传统理论的现代科学内涵。主要研究方向包括：1. 各种疾病和中药对肠道菌群的调节特征研究2. 肠道菌群与药物功效的因果性和内在机制研究3. 肠道菌群与传统中医药理论的内在关系研究 10篇代表性论文(均为通讯作者)：[1]Gut microbiota specifically mediates the anti-hypercholesterolemic effect of berberine (BBR) and facilitates to predict BBR's cholesterol-decreasing efficacy in patients. J Adv Res. 2022. (IF12.822) [2] Gut Microbiota Combined with Metabolites Reveals Unique Features of Acute Myocardial Infarction Patients Different from Stable Coronary Artery Disease. J Adv Res. 2022. (IF12.822) [3]Orally administered Bi2S3@SiO2 core-shell nanomaterials as gastrointestinal contrast agents and their influence on gut microbiota. Mater Today Bio. 2022. (IF10.479) [4] Deep insights into the gut microbial community of extreme longevity in south Chinese centenarians by ultra-deep metagenomics and large-scale culturomics. NPJ Biofilms Microbiomes. 2022 (5-year IF9.667) [5] The Antihyperlipidemic Effects of Fullerenol Nanoparticles via Adjusting the Gut Microbiota in vivo. Part Fibre Toxicol 2018. (5-year IF:9.628) [6]Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction. Nanoscale 2021. (中科院1区，封面论文） [7] Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure. Nanoscale. 2018. (中科院1区) [8] Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase (AMPK)-dependent pathway. Acta Pharm Sin B. 2019. (中科院1区) [9] Marked shifts in gut microbial structure and neurotransmitter metabolism in fresh inmates revealed a close link between gut microbiota and mental health-a case-controlled study. Int J Clin Heal Psych. 2022. (中科院1区) [10] The Traditional Chinese Medicines differentially modulate the gut microbiota on the base of their natures (Yao-Xing). Phytomedicine 2021. (中科院1区) |
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