职称

副研究员

出生年月

1982.11

导师类别

硕导

导师学位

博士

联系电话

/

E-mail

chaixinphd@aliyun.com

招生要求

药物化学及药物分析专业

研究方向

中药药效物质基础及中药质量控制

简介

大学开始受教育经历：

•      2001年~2005年，天津大学，药学院，药学专业学士

•      2005年~2007年，天津大学，药学院，生药学专业硕士

•      2007年~2010年，天津大学，药学院，应用化学专业博士

•      2010年~2013年，天津中医药大学，中药学博士后

•      2013年~今，天津中医药大学，副研究员。目前正在进行的科研项目包括：基于整合组学技术的血府逐瘀汤从“菌”论治的生物学基础研究，基于“量-稳-活”多维网络模式的血府逐瘀胶囊“质控markers”的辨析研究，苦乐果的化学成分研究等。

2005年至今一直从事药用植物的化学成分分离与结构鉴定、生物活性成分筛选、中药质量控制的研究。主持和参与了国家自然科学基金、国家重大新药创制科技重大专项、天津市科技计划项目、国家国际合作项目等重大科研项目；以第一作者或通讯作者发表SCI论文13篇，中文核心期刊论文7篇；以第一发明人申请专利3项，参与申请专利6项。以第11完成人参加课题《基于雌激素样作用的中药物质基础及作用机理差异性研究》，并获得了教育部颁发的科技成果以及科学技术进步一等奖。

代表性论文：

(1) Yuan-Yuan Li, Long Yang, Xin Chai^*, Jun-Jun Yang, Yue-Fei Wang^*, Yan Zhu. Four major urinary metabolites of   liquiritigenin in rats and their anti-platelet aggregation activity. Chemistry   of Natural Compounds 2018, 54(3): 443-446

(2) Hui-Juan Yu^#, Jing Yang^#*, Jia-Min Ding, Ying He, Zhen-Zuo Jiang, Xin Chai^*, Yue-Fei Wang. Stability study and identification   of degradation products of caffeoylgluconic acid derivatives from Fructus   Euodiae. Molecules 2018, 23, 1975

简介

(3) Cong-Cong Li, Teng-Long Wang,   Zhong-Qun Zhang, Wen-Qiang Yang, Yue-Fei Wang, Xin Chai^*, Chun-Hua Wang^*, Zheng Li. Phytochemical and pharmacological studies on the genus Psoralea:   a mini review. Evidence-Based Complementary and Alternative Medicine 2016, 8108643:   1-17

(4) Xin Chai^#*,   Long-Fei Du^#, Jing Yang, Zhen-Zuo Jiang, Long Yang, Yue-Fei   Wang, Yan Zhu. Simultaneous determination of eight constituents in fruits of Rubus   chingii by UPLC. Chinese Herbal Medicines 2016, 8(3): 280-285

(5) Jie Li^#, Long-Fei Du^#,   Ying He, Long Yang, Yuan-Yuan Li, Yue-Fei Wang, Xin Chai^*, Yan Zhu, Xiu-Mei Gao. Chemical constituents and   biological activities of plants from the genus Rubus. Chemistry &   Biodiversity 2015, 12: 1809-1847

(6) Ying He, Jie Li, Hong-Hua Wu, Xin Chai^*, Jing Yang^*, Yue-Fei Wang, Peng Zhang, Yan Zhu, Xiu-Mei   Gao. A new caffeoylgluconic   acid derivative from the nearly ripe fruits of Evodia rutaecarpa.   Natural Product Research 2015, 29(13): 1243-1248

(7) Xiao-Long Zhang, Jie Sun, Hong-Hua   Wu, Ya-Kun Jing, Xin Chai^*,   Yue-Fei Wang. A new   indoloquinazoline alkaloidal glucoside from the nearly ripe fruits of Evodia   rutaecarpa. Natural Product Research 2013, 27(20): 1917-1921

(8)   Xin Chai, Shan-Shan Li, Lin Zhu, Yue-Fei Wang, Xiu-Mei Gao^*.   Chemical constituents of the roots of Trichosanthes kirilowii. Chemistry   of Natural Compounds 2014, 50(5): 965-967

(9)   Xin Chai, Yan-Fang Su^*, Shi-Lun Yan, Xiong Huang. Chemical   constituents of the roots of Triosteum pinnatifidum. Chemistry   of Natural Compounds 2014, 50(6): 1149-1152

(10)   Xin Chai, Yue-Fei Wang^*, Yan-Fang Su, Abdulai J. Bah,   Li-Min Hu, Yue Gao, Xiu-Mei Gao^*. A rapid ultra performance liquid   chromatography-tandem mass spectrometric method for the qualitative and   quantitative analysis of ten compounds in Eucommia ulmodies Oliv.   Journal of Pharmaceutical and Biomedical Analysis 2012, 57: 52-61

(11)   Xin Chai, Yan-Fang Su^*, Jun Zhang, Shi-Lun Yan, Yan-Hong   Gao, Xiu-Mei Gao. A new triterpene and phenolic compounds from the roots of Pteroxygonum   giraldii. Helvetica Chimica Acta 2012, 95(1): 127-133