职    称

特聘研究员

出生年月

1981.9

是否博导

否

学    位

博士

联系电话

/

E-mail

hao_wang@tju.edu.cn

所在单位

天津大学医学工程与转化医学研究院

简  介

(限800字以内)

教育经历

2017-2020，博士后，生物医学工程，哈佛大学医学院

2009-2012，医学博士，放射医学，北京协和医学院

2006-2009，理学硕士，药物化学，北京协和医学院

2000-2004，理学学士，药物制剂，天津医科大学

研究方向

研究方向为小分子药物及超小团簇分子的设计及其在疾病的诊断与治疗中的应用

部分课题

1. β-内酰胺酶自杀基因的构建及其联合放疗治疗肿瘤的实验研究，天津市面上项目，2017-2020，开发靶向性好的β-内酰胺酶自杀基因系统用于肿瘤放射基因疗法

2. β-内酰胺酶自杀基因系统的构建及其合并放疗治疗肿瘤的研究，                 国家自然基金，2014-2016，开发基于β-内酰胺酶的自杀基因系统及其合并放疗用于肿瘤治疗

3. 靶向肿瘤放疗增敏剂—RGDFK-NIDA类化合物的研究，天津市面上项目，2008-2011，主要开发RGD为靶向基团的肿瘤放疗增敏剂

4. 新型吲唑衍生物合成及其辐射防护作用的研究，协和青年骨干教师基金，2013-2014，主要开发小分子电离辐射防护剂

部分文章

1.         Hao Wang#, Xiaoyu Mu#,   Jiang Yang#, Yongye Liang,   Xiao-Dong Zhang, Dong Ming. Brain imaging with   near-infrared fluorophores. Coordination Chemistry Reviews. 2019,   380:550-571.

2.         Hao Wang#,   Xiaoyu Mu#, Hua He, Xiao-Dong Zhang. Cancer radiosensitizers. Trends in   Pharmacological Sciences. 2018, 39 (1): 24-48.

3.         Wang H, Meng AM, Li SH, Zhou XL. A   nanobody targeting Carcinoembryonic antigen as a promising molecular probe   for Non-Small Cell Lung Cancer.  Molecular Medicine Reports.   2017, 16:  625-630.

4.       Wang H, Liu JJ, Zhou XL. Targeting assay of a fusion protein   applied in enzyme prodrug therapy. Oncology Letters, 2017, 13(4):2698-702.

5.         Wang H, Shi PJ, Wu MF, Li   N, Zhou XL, Fan FY. Construction, expression and functional characterization   of the beta-lactamase with alphav integrin ligands. Protein & Peptide   Letters. 2010, 17(12):1562-5.

6.         Wang H, Zhou XL,   Long W, Liu JJ, Fan FY. A Fusion Protein of RGD4C and beta-Lactamase Has a   Favorable Targeting Effect in Its Use in Antibody Directed Enzyme Prodrug   Therapy. International Journal of Molecular Sciences. 2015, 16(5):9625-34.

7.        Zhou XL, Wang H, Shi PJ, Meng AM.   Characterization of a fusion protein of RGD4C and the beta-lactamase variant   for antibody-directed enzyme prodrug therapy. OncoTargets and Therapy.   2014, 7:535-41.

8.       Dong Yang, Hao Wang, Shenglin Luo, Changning   Wang, Sheng Zhang, and Shiqi Guo. 2019. Paper-Cut Flexible Multifunctional   Electronics Using MoS2 Nanosheet. Nanomaterials, 2019, 9(7):  922-937.

9.       Yulong Xu*, Yanli Wang, Hao Wang and Changning   Wang*. Synthesis and Characterization of Carbon-11 Labeled Iloperidone for   Imaging of α1-Adrenoceptor in Brain. Front. Mol. Biosci., 2020, 7: 586327.

10.    Hao Wang, Yu Lan, Ping Bai, Zude Chen,   Shenglin Luo, Yulong Xu, Stephanie Fiedler, Robin Striar, Changning Wang.   Radiosynthesis of [11C]EI1 for imaging EZH2 using positron emission tomography.   Medicinal Chemistry Research. 2020, 2020, 29:2106–2111.

11.   Wei Long, Xiaoyu Mu, Jun-Ying Wang*, Fujuan   Xu, Jiang Yang, Jingya Wang, Si Sun, Jing Chen, Yuan-Ming Sun1, Hao Wang* and   Xiao-Dong Zhang*. Dislocation Engineered PtPdMo Alloy With Enhanced Antioxidant   Activity for Intestinal Injury. Frontiers in Chemistry. 2019, 7:784.