职    称

教授

出生年月

1987.10

是否天中医博导

是

学    位

博士

联系电话

/

E-mail

suncp146@163.com

所在单位

天津中医药大学中药学院

简  介

(限800字以内)

孙成鹏，男，博士，教授。基于多组学靶点识别技术，围绕中药药效物质和作用靶标，开展中药化学生物学研究，以第一或通讯作者在PNAS、ACS Cent. Sci.、J. Hazar. Mater.、Acta Pharm. Sin. B、Int. J. Biol. Sci.、J. Med. Chem.等期刊发表SCI科研论文73篇，其中4篇IF>10，19篇10>IF>7，23篇7>IF>5，单篇最高影响因子18.2，高被引论文2篇。主持国家自然科学基金-面上项目和青年项目2项，省市课题多项，授权发明专利9项，参编教材3部。入选中华中医药学会青年人才托举工程，获辽宁省科技进步二等奖和大连市科技之星称号。担任世界中医药联合会-中药化学专业委员会理事、中国仪器仪表学会药物质量分析与过程控制分会理事、中华中医学会中药化学专业委员会青年委员和大连市药学会天然药物专业委员会委员。担任Front. Chem.客座编辑；担任Anal. Chim Acta、Bioorg. Chem.、Front. Pharmacol.、Phytochemistry、J. Agric. Food Chem.等期刊特约审稿人；担任Acta Materia Medica和沈阳药科大学学报青年编委。

代表性论文：

1. Macrophage inactivation by small   molecule wedelolactone via targeting sEH for the treatment of LPS-induced   acute lung injury. ACS Cent. Sci., 2023, 9, 440-456. (通讯作者，IF=18.2)

2. Kurarinone alleviated   Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal   model. PNAS, 2022, 119, 9, e2118818119. (第一作者，IF= 11.1)

3. Genetic deletion or   pharmacological inhibition of soluble epoxide hydrolase attenuated   particulate matter 2.5 exposure mediated lung injury. J. Hazar. Mater., 2023, 458,   131890. (通讯作者，IF= 13.6)

4. Correlation analysis between the   chemical contents and bioactivity for the quality control of Alismatis Rhizoma.   Acta Pharm. Sin. B, 2018, 8, 242-251. (并列第一作者，IF=14.5)

5. Direct targeting of sEH with alisol   B alleviated the apoptosis, inflammation, and oxidative stress in   cisplatin-induced acute kidney injury. Int. J. Biol. Sci., 2023, 19, 294-310.   (通讯作者，IF=9.2)

6. IκB kinase β (IKKβ): Structure,   transduction mechanism, biological function, and discovery of its inhibitors.   Int. J. Biol. Sci., 2023, 19, 4181-4205. (通讯作者，IF=9.2)

7. Octacyclic and decacyclic   ent-abietane dimers with cytotoxic activity from Euphorbia fischeriana steud.   Chinese Chem. Lett., 2022, 33, 4261-4263. (通讯作者，IF= 9.1)

8. Inhibition effect of   1-acetoxy-6α-(2-methylbutyryl)eriolanolide toward soluble epoxide hydrolase:   Multispectral analysis, molecular dynamics simulation, biochemical, and in   vitro cell-based studies. Int. J. Biol. Macromol., 2023, 235, 123911 (通讯作者，IF= 8.2)

9. Total flavonoids of Inula   japonica alleviated the inflammatory response and oxidative stress in   LPS-induced acute lung injury via inhibiting the sEH activity: Insights from   lipid metabolomics. Phytomedicine, 2022, 107, 154380. (通讯作者，IF= 7.9)

10. Discovery of soluble epoxide hydrolase   inhibitors from chemical synthesis and natural products. J. Med. Chem. 2021,   64, 184-215. (第一作者，IF=7.3)